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Cannabis Extracts in the Fight Against Neuropathic Pain

  • 03 Mar 2025
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A comprehensive review of scientific research has highlighted that cannabis-based treatments may offer significant relief for patients dealing with chronic nerve pain, all while producing "minimal to no side effects." Published in Cureus, this analysis suggests that cannabinoids might serve as a transformative alternative to conventional painkillers, which often bring an array of side effects.

The review examined five placebo-controlled studies from the past two decades, revealing that cannabis-based treatments relieved pain more effectively than placebo alternatives. Specifically, the research noted a significant reduction in pain, with cannabinoids easing symptoms for 33% of patients, compared to just 15% experiencing relief with a placebo. The review also found that CBD, when applied transdermally, offered pronounced relief from sharp, neuropathic pain.

Cannabinoids, derived from the cannabis plant, appeal to many for their natural origins, standing in contrast to synthetic pain medications that can carry more severe side effects. Researchers emphasize that this natural origin may also help ease patient concerns about pharmaceutical reliance, as cannabis-based treatments offer a viable, plant-based option.

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Historic Shifts

The use of marijuana among U.S. adults has more than doubled since 2013. The survey, which uses two-year averages to bolster accuracy, does not specify the mode of cannabis consumption—whether smoking, vaping, or consuming edibles.

Lifetime Use Trends

Gallup's broader questions on lifetime cannabis use reveal that nearly half (47%) of American adults have tried marijuana at least once. This metric has climbed significantly since Gallup first began asking in 1969 when only 4% admitted trying it. By 1977, the number jumped to 24%, continued to 33% by 1985, and hovered below 40% until 2015. Today, it remains just shy of 50%.

This change reflects shifting cultural norms and increasing acceptance of cannabis in American society, amid legislative and social changes regarding its use.